diff --git a/src/vs/workbench/electron-browser/desktop.main.ts b/src/vs/workbench/electron-browser/desktop.main.ts
index 19678d72168fe5d292eeb85315460e4a8ff8c011..93dcb0f386e73e6f024c1351d14666c6b24af6cf 100644
--- a/src/vs/workbench/electron-browser/desktop.main.ts
+++ b/src/vs/workbench/electron-browser/desktop.main.ts
@@ -6,7 +6,7 @@
 import * as fs from 'fs';
 import * as gracefulFs from 'graceful-fs';
 import { createHash } from 'crypto';
-import { stat } from 'vs/base/node/pfs';
+import { exists, stat } from 'vs/base/node/pfs';
 import { isLinux, isMacintosh, isWindows } from 'vs/base/common/platform';
 import { zoomLevelToZoomFactor } from 'vs/platform/windows/common/windows';
 import { mark } from 'vs/base/common/performance';
@@ -21,7 +21,7 @@ import { NativeWorkbenchEnvironmentService } from 'vs/workbench/services/environ
 import { IWorkbenchEnvironmentService } from 'vs/workbench/services/environment/common/environmentService';
 import { INativeWorkbenchConfiguration, INativeWorkbenchEnvironmentService } from 'vs/workbench/services/environment/electron-sandbox/environmentService';
 import { ServiceCollection } from 'vs/platform/instantiation/common/serviceCollection';
-import { ISingleFolderWorkspaceIdentifier, IWorkspaceInitializationPayload, ISingleFolderWorkspaceInitializationPayload, reviveWorkspaceIdentifier } from 'vs/platform/workspaces/common/workspaces';
+import { ISingleFolderWorkspaceIdentifier, IWorkspaceInitializationPayload, ISingleFolderWorkspaceInitializationPayload, reviveWorkspaceIdentifier, IWorkspaceIdentifier, IMultiFolderWorkspaceInitializationPayload } from 'vs/platform/workspaces/common/workspaces';
 import { ILogService } from 'vs/platform/log/common/log';
 import { NativeStorageService } from 'vs/platform/storage/node/storageService';
 import { Schemas } from 'vs/base/common/network';
@@ -280,7 +280,7 @@ class DesktopMain extends Disposable {
 				return service;
 			}),
 
-			this.createKeyboardLayoutService(logService, mainProcessService).then(service => {
+			this.createKeyboardLayoutService(mainProcessService).then(service => {
 
 				// KeyboardLayout
 				serviceCollection.set(IKeyboardLayoutService, service);
@@ -307,15 +307,15 @@ class DesktopMain extends Disposable {
 	}
 
 	private async resolveWorkspaceInitializationPayload(): Promise<IWorkspaceInitializationPayload> {
+		let workspaceInitializationPayload: IWorkspaceInitializationPayload | undefined;
 
 		// Multi-root workspace
 		if (this.configuration.workspace) {
-			return this.configuration.workspace;
+			workspaceInitializationPayload = await this.resolveMultiFolderWorkspaceInitializationPayload(this.configuration.workspace);
 		}
 
 		// Single-folder workspace
-		let workspaceInitializationPayload: IWorkspaceInitializationPayload | undefined;
-		if (this.configuration.folderUri) {
+		else if (this.configuration.folderUri) {
 			workspaceInitializationPayload = await this.resolveSingleFolderWorkspaceInitializationPayload(this.configuration.folderUri);
 		}
 
@@ -336,6 +336,18 @@ class DesktopMain extends Disposable {
 		return workspaceInitializationPayload;
 	}
 
+	private async resolveMultiFolderWorkspaceInitializationPayload(workspace: IWorkspaceIdentifier): Promise<IMultiFolderWorkspaceInitializationPayload | undefined> {
+
+		// It is possible that the workspace file does not exist
+		// on disk anymore, so we return `undefined` in that case
+		// (https://github.com/microsoft/vscode/issues/110982)
+		if (workspace.configPath.scheme === Schemas.file && !await exists(workspace.configPath.fsPath)) {
+			return undefined;
+		}
+
+		return workspace;
+	}
+
 	private async resolveSingleFolderWorkspaceInitializationPayload(folderUri: ISingleFolderWorkspaceIdentifier): Promise<ISingleFolderWorkspaceInitializationPayload | undefined> {
 		try {
 			const folder = folderUri.scheme === Schemas.file
@@ -388,7 +400,6 @@ class DesktopMain extends Disposable {
 			return workspaceService;
 		} catch (error) {
 			onUnexpectedError(error);
-			logService.error(error);
 
 			return workspaceService;
 		}
@@ -404,13 +415,12 @@ class DesktopMain extends Disposable {
 			return storageService;
 		} catch (error) {
 			onUnexpectedError(error);
-			logService.error(error);
 
 			return storageService;
 		}
 	}
 
-	private async createKeyboardLayoutService(logService: ILogService, mainProcessService: IMainProcessService): Promise<KeyboardLayoutService> {
+	private async createKeyboardLayoutService(mainProcessService: IMainProcessService): Promise<KeyboardLayoutService> {
 		const keyboardLayoutService = new KeyboardLayoutService(mainProcessService);
 
 		try {
@@ -419,7 +429,6 @@ class DesktopMain extends Disposable {
 			return keyboardLayoutService;
 		} catch (error) {
 			onUnexpectedError(error);
-			logService.error(error);
 
 			return keyboardLayoutService;
 		}