diff --git a/tools/gn b/tools/gn
index 5f07e7736c1b84e2b7df28fff390069f0538520d..f05743bb508c64e419fed0728ab00b81d8664e31 100755
--- a/tools/gn
+++ b/tools/gn
@@ -380,6 +380,11 @@ def to_gn_args(args):
     # on Android.
     gn_args['bssl_use_clang_integrated_as'] = True
 
+    # Enable pointer compression on 64-bit mobile targets.
+    if (args.target_os == 'android' or args.target_os == 'ios') and (
+        gn_args['target_cpu'] == 'x64' or gn_args['target_cpu'] == 'arm64'):
+      gn_args['dart_use_compressed_pointers'] = True
+
     return gn_args
 
 def parse_args(args):