diff --git a/apm-sniffer/apm-sdk-plugin/okhttp-3.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/okhttp/v3/RealCallInterceptor.java b/apm-sniffer/apm-sdk-plugin/okhttp-3.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/okhttp/v3/RealCallInterceptor.java
index e00c747156aac2e4261061a2781c9173b516746e..d9a9ae7abf8867788b105bbe7431a40b6e76648b 100644
--- a/apm-sniffer/apm-sdk-plugin/okhttp-3.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/okhttp/v3/RealCallInterceptor.java
+++ b/apm-sniffer/apm-sdk-plugin/okhttp-3.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/okhttp/v3/RealCallInterceptor.java
@@ -100,12 +100,13 @@ public class RealCallInterceptor implements InstanceMethodsAroundInterceptor, In
     public Object afterMethod(EnhancedInstance objInst, Method method, Object[] allArguments,
         Class<?>[] argumentsTypes, Object ret) throws Throwable {
         Response response = (Response)ret;
-        int statusCode = response.code();
-
-        AbstractSpan span = ContextManager.activeSpan();
-        if (statusCode >= 400) {
-            span.errorOccurred();
-            Tags.STATUS_CODE.set(span, Integer.toString(statusCode));
+        if (response != null) {
+            int statusCode = response.code();
+            AbstractSpan span = ContextManager.activeSpan();
+            if (statusCode >= 400) {
+                span.errorOccurred();
+                Tags.STATUS_CODE.set(span, Integer.toString(statusCode));
+            }
         }
 
         ContextManager.stopSpan();