diff --git a/lite/backends/arm/math/prior_box.cc b/lite/backends/arm/math/prior_box.cc
index 4ef7356e67cee4c47ddf3eb16ed5286b4271b41a..6daab69ebf00da24d67132afba4b9abef0afbd39 100644
--- a/lite/backends/arm/math/prior_box.cc
+++ b/lite/backends/arm/math/prior_box.cc
@@ -21,7 +21,7 @@ namespace lite {
 namespace arm {
 namespace math {
 
-const int MALLOC_ALIGN = 16;
+const int MALLOC_ALIGN = 64;
 
 void* fast_malloc(size_t size) {
   size_t offset = sizeof(void*) + MALLOC_ALIGN - 1;
diff --git a/lite/backends/host/target_wrapper.cc b/lite/backends/host/target_wrapper.cc
index 00ce9dd6b349decc2f603692c2a6a0801bd4d7c0..3cc02f515a3b44ee176e99523fd7c810a1ac6a9f 100644
--- a/lite/backends/host/target_wrapper.cc
+++ b/lite/backends/host/target_wrapper.cc
@@ -19,7 +19,7 @@
 namespace paddle {
 namespace lite {
 
-const int MALLOC_ALIGN = 16;
+const int MALLOC_ALIGN = 64;
 
 void* TargetWrapper<TARGET(kHost)>::Malloc(size_t size) {
   size_t offset = sizeof(void*) + MALLOC_ALIGN - 1;
diff --git a/lite/tests/kernels/prior_box_compute_test.cc b/lite/tests/kernels/prior_box_compute_test.cc
index ec0eda8cbb2b7f8d6ab01efa467ed857d817905a..73fd612c3a03c0a15ddaf3ce6c08ff0ed1a5a95b 100644
--- a/lite/tests/kernels/prior_box_compute_test.cc
+++ b/lite/tests/kernels/prior_box_compute_test.cc
@@ -21,7 +21,7 @@
 namespace paddle {
 namespace lite {
 
-const int MALLOC_ALIGN = 16;
+const int MALLOC_ALIGN = 64;
 
 void* fast_malloc(size_t size) {
   size_t offset = sizeof(void*) + MALLOC_ALIGN - 1;