diff --git a/drivers/tty/serial/8250/Kconfig b/drivers/tty/serial/8250/Kconfig
index a5c0ef1e7695fedc6e185e09454d9a5a55f358cb..16b1496e61051948ff38ab2f884632c30a7389c7 100644
--- a/drivers/tty/serial/8250/Kconfig
+++ b/drivers/tty/serial/8250/Kconfig
@@ -5,6 +5,7 @@
 
 config SERIAL_8250
 	tristate "8250/16550 and compatible serial support"
+	depends on !S390
 	select SERIAL_CORE
 	---help---
 	  This selects whether you want to include the driver for the standard