diff --git a/target/s390x/sigp.c b/target/s390x/sigp.c
index d70f5cb0baecec12a20aa8537c1637ef96524223..c5a5dac9117f51dc06b809bf6bfe4b420f009251 100644
--- a/target/s390x/sigp.c
+++ b/target/s390x/sigp.c
@@ -287,6 +287,7 @@ static void sigp_set_prefix(CPUState *cs, run_on_cpu_data arg)
     }
 
     cpu->env.psa = addr;
+    tlb_flush(cs);
     cpu_synchronize_post_init(cs);
     si->cc = SIGP_CC_ORDER_CODE_ACCEPTED;
 }