diff --git a/hw/s390x/s390-pci-bus.c b/hw/s390x/s390-pci-bus.c
index 77a50cab36168a88f1ebe80d318992fd8dddd9e4..10da87458ee2c4215973233a8fb94152adf203e5 100644
--- a/hw/s390x/s390-pci-bus.c
+++ b/hw/s390x/s390-pci-bus.c
@@ -816,6 +816,11 @@ static void s390_pcihost_hot_plug(HotplugHandler *hotplug_dev,
         PCIBridge *pb = PCI_BRIDGE(dev);
         PCIDevice *pdev = PCI_DEVICE(dev);
 
+        if (pdev->cap_present & QEMU_PCI_CAP_MULTIFUNCTION) {
+            error_setg(errp, "multifunction not supported in s390");
+            return;
+        }
+
         pci_bridge_map_irq(pb, dev->id, s390_pci_map_irq);
         pci_setup_iommu(&pb->sec_bus, s390_pci_dma_iommu, s);
 
@@ -835,6 +840,11 @@ static void s390_pcihost_hot_plug(HotplugHandler *hotplug_dev,
     } else if (object_dynamic_cast(OBJECT(dev), TYPE_PCI_DEVICE)) {
         pdev = PCI_DEVICE(dev);
 
+        if (pdev->cap_present & QEMU_PCI_CAP_MULTIFUNCTION) {
+            error_setg(errp, "multifunction not supported in s390");
+            return;
+        }
+
         if (!dev->id) {
             /* In the case the PCI device does not define an id */
             /* we generate one based on the PCI address         */