diff --git a/linux-user/syscall_defs.h b/linux-user/syscall_defs.h
index 5a580100cb2ad9cbb60016abe9b50574e98932fa..41a9dd6ab192c8040fb4f8bf1f1810514ee921e5 100644
--- a/linux-user/syscall_defs.h
+++ b/linux-user/syscall_defs.h
@@ -1749,6 +1749,25 @@ struct target_statfs64 {
 #define TARGET_O_NOFOLLOW	0x20000	/* don't follow links */
 #define TARGET_O_NOATIME	0x40000
 #define TARGET_O_NDELAY	TARGET_O_NONBLOCK
+#elif defined(TARGET_ALPHA)
+#define TARGET_O_ACCMODE	0x0003
+#define TARGET_O_RDONLY	0x0000
+#define TARGET_O_WRONLY	0x0001
+#define TARGET_O_RDWR		0x0002
+#define TARGET_O_APPEND	0x0008
+#define TARGET_O_SYNC		0x4000
+#define TARGET_O_NONBLOCK	0x0004
+#define TARGET_O_CREAT         0x0200	/* not fcntl */
+#define TARGET_O_TRUNC		0x0400	/* not fcntl */
+#define TARGET_O_EXCL		0x0800	/* not fcntl */
+#define TARGET_O_NOCTTY	0x1000	/* not fcntl */
+#define TARGET_FASYNC		0x2000	/* fcntl, for BSD compatibility */
+#define TARGET_O_LARGEFILE	0x0000	/* not necessary, always 64-bit */
+#define TARGET_O_DIRECT	0x80000	/* direct disk access hint */
+#define TARGET_O_DIRECTORY	0x8000	/* must be a directory */
+#define TARGET_O_NOFOLLOW	0x10000	/* don't follow links */
+#define TARGET_O_NOATIME	0x100000
+#define TARGET_O_NDELAY	TARGET_O_NONBLOCK
 #else
 #define TARGET_O_ACCMODE          0003
 #define TARGET_O_RDONLY             00