diff --git a/src/util/virnetdevmacvlan.c b/src/util/virnetdevmacvlan.c
index d8d1d901f922e7cbd40d61ac78dce3c7793d983b..8fc71af4354550767a697b5fbfa631d8071cf9dd 100644
--- a/src/util/virnetdevmacvlan.c
+++ b/src/util/virnetdevmacvlan.c
@@ -334,10 +334,18 @@ virNetDevMacVLanTapSetup(int *tapfd, size_t tapfdSize, bool vnet_hdr, bool multi
             new_flags &= ~IFF_VNET_HDR;
         }
 
+# ifdef IFF_MULTI_QUEUE
         if (multiqueue)
             new_flags |= IFF_MULTI_QUEUE;
         else
             new_flags &= ~IFF_MULTI_QUEUE;
+# else
+        if (multiqueue) {
+            virReportError(VIR_ERR_CONFIG_UNSUPPORTED, "%s",
+                           _("Multiqueue devices are not supported on this system"));
+            return -1;
+        }
+# endif
 
         if (new_flags != ifreq.ifr_flags) {
             ifreq.ifr_flags = new_flags;