diff --git a/configure.ac b/configure.ac
index 6744ace5785890543bcf6c428df08803ed6c6418..a60543072dbb3a212cc1906de9cee6aa72a82b0f 100644
--- a/configure.ac
+++ b/configure.ac
@@ -212,6 +212,7 @@ fi
 
 AM_CONDITIONAL([WITH_LINUX], [test "$with_linux" = "yes"])
 AM_CONDITIONAL([WITH_FREEBSD], [test "$with_freebsd" = "yes"])
+AM_CONDITIONAL([WITH_MACOS], [test "$with_macos" = "yes"])
 
 # We don't support the daemon yet
 if test "$with_win" = "yes" ; then
diff --git a/src/Makefile.am b/src/Makefile.am
index 817a7ecf34645a2424e311ab64ecc723ab6c2bd9..adaf61350a441b5bc903b5327ae88fbf6da9cb31 100644
--- a/src/Makefile.am
+++ b/src/Makefile.am
@@ -579,8 +579,13 @@ libvirt_la_LDFLAGS = \
 		-version-info $(LIBVIRT_VERSION_INFO) \
 		$(LIBVIRT_NODELETE) \
 		$(NO_UNDEFINED_LDFLAGS) \
-		$(AM_LDFLAGS) \
-		$(NULL)
+		$(AM_LDFLAGS)
+if WITH_MACOS
+# macOS has two-level namespaces by default.
+# Override it to allow symbol replacement with DYLD_INSERT_LIBRARIES
+libvirt_la_LDFLAGS += -Wl,-flat_namespace
+endif WITH_MACOS
+libvirt_la_LDFLAGS += $(NULL)
 libvirt_la_BUILT_LIBADD += ../gnulib/lib/libgnu.la
 libvirt_la_LIBADD += \
 		    $(DRIVER_MODULES_LIBS) \