diff --git a/src/qemu/qemu_command.c b/src/qemu/qemu_command.c
index 4a430ddfbac059e69047afed1981f638340f183a..373ebd6d1a9244f83c0c0b6d34f780fe78f83d79 100644
--- a/src/qemu/qemu_command.c
+++ b/src/qemu/qemu_command.c
@@ -5375,6 +5375,7 @@ qemuBuildChrChardevStr(virLogManagerPtr logManager,
     return virBufferContentAndReset(&buf);
 }
 
+
 char *
 qemuBuildHostdevMediatedDevStr(const virDomainDef *def,
                                virDomainHostdevDefPtr dev,
@@ -5403,6 +5404,9 @@ qemuBuildHostdevMediatedDevStr(const virDomainDef *def,
     if (qemuBuildDeviceAddressStr(&buf, def, dev->info, qemuCaps) < 0)
         return NULL;
 
+    if (dev->info->bootIndex)
+        virBufferAsprintf(&buf, ",bootindex=%u", dev->info->bootIndex);
+
     if (virBufferCheckError(&buf) < 0)
         return NULL;
 
diff --git a/src/qemu/qemu_domain.c b/src/qemu/qemu_domain.c
index 581b48bcf741425f9ada720a8b4f20467891fd0e..4998474dc91a955bb06ebc5a1d611d642a2c181a 100644
--- a/src/qemu/qemu_domain.c
+++ b/src/qemu/qemu_domain.c
@@ -5196,6 +5196,15 @@ qemuDomainMdevDefVFIOPCIValidate(const virDomainHostdevDef *hostdev,
 {
     const virDomainHostdevSubsysMediatedDev *dev;
 
+    /* VFIO-PCI does not support boot */
+    if (hostdev->info->bootIndex) {
+        virReportError(VIR_ERR_CONFIG_UNSUPPORTED, "%s",
+                       _("booting from assigned devices is not "
+                         "supported by mediated devices of "
+                         "model vfio-pci"));
+        return -1;
+    }
+
     dev = &hostdev->source.subsys.u.mdev;
     if (dev->display == VIR_TRISTATE_SWITCH_ABSENT)
         return 0;
@@ -5229,12 +5238,21 @@ qemuDomainMdevDefVFIOPCIValidate(const virDomainHostdevDef *hostdev,
 
 
 static int
-qemuDomainMdevDefVFIOAPValidate(const virDomainHostdevDef *hostdev ATTRIBUTE_UNUSED,
+qemuDomainMdevDefVFIOAPValidate(const virDomainHostdevDef *hostdev,
                                 const virDomainDef *def)
 {
     size_t i;
     bool vfioap_found = false;
 
+    /* VFIO-AP does not support boot */
+    if (hostdev->info->bootIndex) {
+        virReportError(VIR_ERR_CONFIG_UNSUPPORTED, "%s",
+                       _("booting from assigned devices is not "
+                         "supported by mediated devices of "
+                         "model vfio-ap"));
+        return -1;
+    }
+
     /* VFIO-AP is restricted to a single mediated device only */
     for (i = 0; i < def->nhostdevs; i++) {
         virDomainHostdevDefPtr hdev = def->hostdevs[i];
@@ -5310,12 +5328,6 @@ qemuDomainDeviceDefValidateHostdev(const virDomainHostdevDef *hostdev,
             }
             break;
         case VIR_DOMAIN_HOSTDEV_SUBSYS_TYPE_MDEV:
-            if (hostdev->info->bootIndex) {
-                virReportError(VIR_ERR_CONFIG_UNSUPPORTED, "%s",
-                               _("booting from assigned devices is not "
-                                 "supported by mediated devices"));
-                return -1;
-            }
             return qemuDomainMdevDefValidate(hostdev, def, qemuCaps);
         case VIR_DOMAIN_HOSTDEV_SUBSYS_TYPE_LAST:
         default:
diff --git a/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.args b/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.args
new file mode 100644
index 0000000000000000000000000000000000000000..aef2eb37fc9466a8c0665c753cc5aff80122b7dd
--- /dev/null
+++ b/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.args
@@ -0,0 +1,34 @@
+LC_ALL=C \
+PATH=/bin \
+HOME=/tmp/lib/domain--1-QEMUGuest1 \
+USER=test \
+LOGNAME=test \
+XDG_DATA_HOME=/tmp/lib/domain--1-QEMUGuest1/.local/share \
+XDG_CACHE_HOME=/tmp/lib/domain--1-QEMUGuest1/.cache \
+XDG_CONFIG_HOME=/tmp/lib/domain--1-QEMUGuest1/.config \
+QEMU_AUDIO_DRV=none \
+/usr/bin/qemu-system-s390x \
+-name guest=QEMUGuest1,debug-threads=on \
+-S \
+-object secret,id=masterKey0,format=raw,\
+file=/tmp/lib/domain--1-QEMUGuest1/master-key.aes \
+-machine s390-ccw-virtio,accel=tcg,usb=off,dump-guest-core=off \
+-m 512 \
+-overcommit mem-lock=off \
+-smp 2,sockets=2,cores=1,threads=1 \
+-uuid c7a5fdbd-edaf-9455-926a-d65c16db1809 \
+-display none \
+-no-user-config \
+-nodefaults \
+-chardev socket,id=charmonitor,fd=1729,server,nowait \
+-mon chardev=charmonitor,id=monitor,mode=control \
+-rtc base=utc \
+-no-shutdown \
+-boot strict=on \
+-device vfio-ccw,id=hostdev0,\
+sysfsdev=/sys/bus/mdev/devices/90c6c135-ad44-41d0-b1b7-bae47de48627,\
+devno=fe.0.0000,bootindex=1 \
+-device virtio-balloon-ccw,id=balloon0,devno=fe.0.0001 \
+-sandbox on,obsolete=deny,elevateprivileges=deny,spawn=deny,\
+resourcecontrol=deny \
+-msg timestamp=on
diff --git a/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.xml b/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.xml
new file mode 100644
index 0000000000000000000000000000000000000000..6cca13c33f85c5f8484e0bcc6e69e12419362ff4
--- /dev/null
+++ b/tests/qemuxml2argvdata/hostdev-subsys-mdev-vfio-ccw-boot.xml
@@ -0,0 +1,23 @@
+<domain type='qemu'>
+  <name>QEMUGuest1</name>
+  <uuid>c7a5fdbd-edaf-9455-926a-d65c16db1809</uuid>
+  <memory unit='KiB'>524288</memory>
+  <currentMemory unit='KiB'>524288</currentMemory>
+  <vcpu placement='static'>2</vcpu>
+  <os>
+    <type arch='s390x' machine='s390-ccw-virtio'>hvm</type>
+  </os>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>destroy</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu-system-s390x</emulator>
+    <hostdev mode='subsystem' type='mdev' model='vfio-ccw'>
+      <source>
+        <address uuid='90c6c135-ad44-41d0-b1b7-bae47de48627'/>
+      </source>
+      <boot order='1'/>
+    </hostdev>
+  </devices>
+</domain>
diff --git a/tests/qemuxml2argvtest.c b/tests/qemuxml2argvtest.c
index 59be85613e13d96738f4c7032a0301ced2eacc11..9395cc19a2a553c2d6ac28dfeecd2f83c1cd1245 100644
--- a/tests/qemuxml2argvtest.c
+++ b/tests/qemuxml2argvtest.c
@@ -1625,6 +1625,8 @@ mymain(void)
             QEMU_CAPS_CCW,
             QEMU_CAPS_CCW_CSSID_UNRESTRICTED,
             QEMU_CAPS_DEVICE_VFIO_CCW);
+    DO_TEST_CAPS_ARCH_LATEST("hostdev-subsys-mdev-vfio-ccw-boot",
+                             "s390x");
     DO_TEST_FAILURE("hostdev-subsys-mdev-vfio-ccw",
             QEMU_CAPS_CCW,
             QEMU_CAPS_CCW_CSSID_UNRESTRICTED);
diff --git a/tests/qemuxml2xmloutdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.xml b/tests/qemuxml2xmloutdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.xml
new file mode 100644
index 0000000000000000000000000000000000000000..68defea44cece873d007cebdebdb250e4216e08c
--- /dev/null
+++ b/tests/qemuxml2xmloutdata/hostdev-subsys-mdev-vfio-ccw-boot.s390x-latest.xml
@@ -0,0 +1,29 @@
+<domain type='qemu'>
+  <name>QEMUGuest1</name>
+  <uuid>c7a5fdbd-edaf-9455-926a-d65c16db1809</uuid>
+  <memory unit='KiB'>524288</memory>
+  <currentMemory unit='KiB'>524288</currentMemory>
+  <vcpu placement='static'>2</vcpu>
+  <os>
+    <type arch='s390x' machine='s390-ccw-virtio'>hvm</type>
+  </os>
+  <clock offset='utc'/>
+  <on_poweroff>destroy</on_poweroff>
+  <on_reboot>restart</on_reboot>
+  <on_crash>destroy</on_crash>
+  <devices>
+    <emulator>/usr/bin/qemu-system-s390x</emulator>
+    <controller type='pci' index='0' model='pci-root'/>
+    <hostdev mode='subsystem' type='mdev' managed='no' model='vfio-ccw'>
+      <source>
+        <address uuid='90c6c135-ad44-41d0-b1b7-bae47de48627'/>
+      </source>
+      <boot order='1'/>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0000'/>
+    </hostdev>
+    <memballoon model='virtio'>
+      <address type='ccw' cssid='0xfe' ssid='0x0' devno='0x0001'/>
+    </memballoon>
+    <panic model='s390'/>
+  </devices>
+</domain>
diff --git a/tests/qemuxml2xmltest.c b/tests/qemuxml2xmltest.c
index 93ead52d9a4931a636461e7342f29d46f3d0ca5d..5f6a3618cdd91131f999a8e6bf9eb3aaa20743b4 100644
--- a/tests/qemuxml2xmltest.c
+++ b/tests/qemuxml2xmltest.c
@@ -959,6 +959,8 @@ mymain(void)
             QEMU_CAPS_CCW,
             QEMU_CAPS_CCW_CSSID_UNRESTRICTED,
             QEMU_CAPS_DEVICE_VFIO_CCW);
+    DO_TEST_CAPS_ARCH_LATEST("hostdev-subsys-mdev-vfio-ccw-boot",
+                             "s390x");
     DO_TEST("hostdev-subsys-mdev-vfio-ap",
             QEMU_CAPS_CCW,
             QEMU_CAPS_CCW_CSSID_UNRESTRICTED,