diff --git a/drivers/scsi/g_NCR5380.c b/drivers/scsi/g_NCR5380.c
index cd79ef402d7a88fe6981bccd4565c735da158d96..454b565c0417bba2e477991df24435b8b98241a4 100644
--- a/drivers/scsi/g_NCR5380.c
+++ b/drivers/scsi/g_NCR5380.c
@@ -702,6 +702,10 @@ static int generic_NCR5380_dma_xfer_len(struct scsi_cmnd *cmd)
 	    !(cmd->SCp.this_residual % transfersize))
 		transfersize = 32 * 1024;
 
+	/* 53C400 datasheet: non-modulo-128-byte transfers should use PIO */
+	if (transfersize % 128)
+		transfersize = 0;
+
 	return transfersize;
 }