diff --git a/src/Compilers/Server/VBCSCompilerTests/CompilerServerApiTest.cs b/src/Compilers/Server/VBCSCompilerTests/CompilerServerApiTest.cs
index 876ae0c08e0ad2453a717e61e078cdb81e1023c3..45659e9427acbb7034b96a0340f2b137bf0e70a5 100644
--- a/src/Compilers/Server/VBCSCompilerTests/CompilerServerApiTest.cs
+++ b/src/Compilers/Server/VBCSCompilerTests/CompilerServerApiTest.cs
@@ -542,5 +542,39 @@ public async Task IncorrectServerHashReturnsIncorrectHashResponse()
                 Assert.Equal(BuildResponse.ResponseType.IncorrectHash, buildResponse.Type);
             }
         }
+
+        [ConditionalFact(typeof(WindowsDesktopOnly))]
+        [WorkItem(33452, "https://github.com/dotnet/roslyn/issues/33452")]
+        public void QuotePipeName_Desktop()
+        {
+            var serverInfo = BuildServerConnection.GetServerProcessInfo(@"q:\tools", "name with space");
+            Assert.Equal(@"q:\tools\VBCSCompiler.exe", serverInfo.processFilePath);
+            Assert.Equal(@"q:\tools\VBCSCompiler.exe", serverInfo.toolFilePath);
+            Assert.Equal(@"""-pipename:name with space""", serverInfo.commandLineArguments);
+        }
+
+        [ConditionalFact(typeof(CoreClrOnly))]
+        [WorkItem(33452, "https://github.com/dotnet/roslyn/issues/33452")]
+        public void QuotePipeName_CoreClr()
+        {
+            var toolDir = ExecutionConditionUtil.IsWindows
+                ? @"q:\tools"
+                : "/tools";
+            var serverInfo = BuildServerConnection.GetServerProcessInfo(toolDir, "name with space");
+            var vbcsFilePath = Path.Combine(toolDir, "VBCSCompiler.dll");
+            Assert.Equal(vbcsFilePath, serverInfo.toolFilePath);
+            Assert.Equal($@"exec ""{vbcsFilePath}"" ""-pipename:name with space""", serverInfo.commandLineArguments);
+        }
+
+        [Theory]
+        [InlineData(@"name with space.T.basename", "name with space", true, "basename")]
+        [InlineData(@"ha_ha.T.basename", @"ha""ha", true, "basename")]
+        [InlineData(@"jared.T.ha_ha", @"jared", true, @"ha""ha")]
+        [InlineData(@"jared.F.ha_ha", @"jared", false, @"ha""ha")]
+        [InlineData(@"jared.F.ha_ha", @"jared", false, @"ha\ha")]
+        public void GetPipeNameCore(string expectedName, string userName, bool isAdmin, string basePipeName)
+        {
+            Assert.Equal(expectedName, BuildServerConnection.GetPipeNameCore(userName, isAdmin, basePipeName));
+        }
     }
 }
diff --git a/src/Compilers/Shared/BuildServerConnection.cs b/src/Compilers/Shared/BuildServerConnection.cs
index 67efa1d6de0c70a5046e6e68263aa28811cbfc5a..496bb756f6d05db975ba0f33809eecb4631af83a 100644
--- a/src/Compilers/Shared/BuildServerConnection.cs
+++ b/src/Compilers/Shared/BuildServerConnection.cs
@@ -378,10 +378,16 @@ internal static bool IsCompilerServerSupported(string tempPath)
             }
         }
 
-        internal static bool TryCreateServerCore(string clientDir, string pipeName)
+        internal static (string processFilePath, string commandLineArguments, string toolFilePath) GetServerProcessInfo(string clientDir, string pipeName)
         {
             var serverPathWithoutExtension = Path.Combine(clientDir, "VBCSCompiler");
-            var serverInfo = RuntimeHostInfo.GetProcessInfo(serverPathWithoutExtension, $"-pipename:{pipeName}");
+            var commandLineArgs = $@"""-pipename:{pipeName}""";
+            return RuntimeHostInfo.GetProcessInfo(serverPathWithoutExtension, commandLineArgs);
+        }
+
+        internal static bool TryCreateServerCore(string clientDir, string pipeName)
+        {
+            var serverInfo = GetServerProcessInfo(clientDir, pipeName);
 
             if (!File.Exists(serverInfo.toolFilePath))
             {
@@ -480,7 +486,24 @@ internal static string GetPipeNameForPathOpt(string compilerExeDirectory)
                 return null;
             }
 
-            return $"{userName}.{(isAdmin ? 'T' : 'F')}.{basePipeName}";
+            return GetPipeNameCore(userName, isAdmin, basePipeName);
+        }
+
+        internal static string GetPipeNameCore(string userName, bool isAdmin, string basePipeName)
+        {
+            var pipeName = $"{userName}.{(isAdmin ? 'T' : 'F')}.{basePipeName}";
+
+            // The pipe name is passed between processes as a command line argument as a 
+            // quoted value. Unfortunately we can't use ProcessStartInfo.ArgumentList as 
+            // we still target net472 (API only available on CoreClr + netstandard). To 
+            // make the problem approachable we remove the troublesome characters.
+            //
+            // This does mean if two users on the same machine are building simultaneously
+            // and the user names differ only be a " or / and a _ then there will be a 
+            // conflict. That seems rather obscure though.
+            return pipeName
+                .Replace('"', '_')
+                .Replace('\\', '_');
         }
 
         /// <summary>
diff --git a/src/Test/Utilities/Portable/Assert/ConditionalFactAttribute.cs b/src/Test/Utilities/Portable/Assert/ConditionalFactAttribute.cs
index 5c7cfb72b0c8f1f02e782a73484f4ebe12dedfef..640694999fa6598f76c426d6c91a44d54fe294fd 100644
--- a/src/Test/Utilities/Portable/Assert/ConditionalFactAttribute.cs
+++ b/src/Test/Utilities/Portable/Assert/ConditionalFactAttribute.cs
@@ -225,6 +225,12 @@ public class ClrOnly : ExecutionCondition
         public override string SkipReason => "Test not supported on Mono";
     }
 
+    public class CoreClrOnly : ExecutionCondition
+    {
+        public override bool ShouldSkip => !ExecutionConditionUtil.IsCoreClr;
+        public override string SkipReason => "Test only supported on CoreClr";
+    }
+
     public class DesktopOnly : ExecutionCondition
     {
         public override bool ShouldSkip => !ExecutionConditionUtil.IsDesktop;