diff --git a/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
index bea877b05ff2cabfaf5bf5ff64a132c9c5b08e5a..b50e1ca6990cd6987aff67a4a57279eb9fe58ef1 100644
--- a/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
+++ b/apm-sniffer/apm-sdk-plugin/mysql-5.x-plugin/src/main/java/org/apache/skywalking/apm/plugin/jdbc/mysql/define/DriverInstrumentation.java
@@ -32,6 +32,8 @@ import static org.apache.skywalking.apm.plugin.jdbc.mysql.define.MultiClassNameM
 public class DriverInstrumentation extends AbstractDriverInstrumentation {
     @Override
     protected ClassMatch enhanceClass() {
-        return byMultiClassMatch("com.mysql.jdbc.Driver", "com.mysql.cj.jdbc.Driver");
+        return byMultiClassMatch("com.mysql.jdbc.Driver", "com.mysql.cj.jdbc.Driver"
+                    ,"com.mysql.jdbc.NonRegisteringDriver"  //Add this for support MysqlDataSource and MysqlXADatasource
+                );
     }
 }