diff --git a/src/doc/unstable-book/src/language-features/cfg-sanitize.md b/src/doc/unstable-book/src/language-features/cfg-sanitize.md
new file mode 100644
index 0000000000000000000000000000000000000000..949f24ab9c11eb5337050c3fadfdc51bcf3bcf91
--- /dev/null
+++ b/src/doc/unstable-book/src/language-features/cfg-sanitize.md
@@ -0,0 +1,36 @@
+# `cfg_sanitize`
+
+The tracking issue for this feature is: [#39699]
+
+[#39699]: https://github.com/rust-lang/rust/issues/39699
+
+------------------------
+
+The `cfg_sanitize` feature makes it possible to execute different code
+depending on whether a particular sanitizer is enabled or not.
+
+## Examples
+
+``` rust
+#![feature(cfg_sanitize)]
+
+#[cfg(sanitize = "thread")]
+fn a() {
+  // ...
+}
+
+#[cfg(not(sanitize = "thread"))]
+fn a() {
+  // ...
+}
+
+fn b() {
+  if cfg!(sanitize = "leak") {
+    // ...
+  } else {
+    // ...
+  }
+}
+
+```
+
diff --git a/src/librustc/session/config.rs b/src/librustc/session/config.rs
index d2ac5436cc8025e3e889462f593151fe1a1b620f..9a242d9d0769b4517278d009ec211d35be44ad8c 100644
--- a/src/librustc/session/config.rs
+++ b/src/librustc/session/config.rs
@@ -47,6 +47,17 @@ pub enum Sanitizer {
     Thread,
 }
 
+impl fmt::Display for Sanitizer {
+    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
+        match *self {
+            Sanitizer::Address => "address".fmt(f),
+            Sanitizer::Leak => "leak".fmt(f),
+            Sanitizer::Memory => "memory".fmt(f),
+            Sanitizer::Thread => "thread".fmt(f),
+        }
+    }
+}
+
 impl FromStr for Sanitizer {
     type Err = ();
     fn from_str(s: &str) -> Result<Sanitizer, ()> {
@@ -1580,6 +1591,10 @@ pub fn default_configuration(sess: &Session) -> ast::CrateConfig {
             }
         }
     }
+    if let Some(s) = &sess.opts.debugging_opts.sanitizer {
+        let symbol = Symbol::intern(&s.to_string());
+        ret.insert((sym::sanitize, Some(symbol)));
+    }
     if sess.opts.debug_assertions {
         ret.insert((Symbol::intern("debug_assertions"), None));
     }
diff --git a/src/librustc_feature/active.rs b/src/librustc_feature/active.rs
index 7c0d39965fc00ff0522ed544827aae6a2f4d35e9..16d8ada9f24c0857f93c2c29f662da0bfbd1d76c 100644
--- a/src/librustc_feature/active.rs
+++ b/src/librustc_feature/active.rs
@@ -524,6 +524,9 @@ pub fn set(&self, features: &mut Features, span: Span) {
     /// Allows the use of `if` and `match` in constants.
     (active, const_if_match, "1.41.0", Some(49146), None),
 
+    /// Allows the use of `#[cfg(sanitize = "option")]`; set when -Zsanitizer is used.
+    (active, cfg_sanitize, "1.41.0", Some(39699), None),
+
     // -------------------------------------------------------------------------
     // feature-group-end: actual feature gates
     // -------------------------------------------------------------------------
diff --git a/src/librustc_feature/builtin_attrs.rs b/src/librustc_feature/builtin_attrs.rs
index 9c936492cbded40e3810566fdcd3a77be7bc1cde..4fa0198d8716d2463d49f9e1ca56f2cd58418040 100644
--- a/src/librustc_feature/builtin_attrs.rs
+++ b/src/librustc_feature/builtin_attrs.rs
@@ -25,6 +25,7 @@
     (sym::target_thread_local, sym::cfg_target_thread_local, cfg_fn!(cfg_target_thread_local)),
     (sym::target_has_atomic, sym::cfg_target_has_atomic, cfg_fn!(cfg_target_has_atomic)),
     (sym::target_has_atomic_load_store, sym::cfg_target_has_atomic, cfg_fn!(cfg_target_has_atomic)),
+    (sym::sanitize, sym::cfg_sanitize, cfg_fn!(cfg_sanitize)),
 ];
 
 /// Find a gated cfg determined by the `pred`icate which is given the cfg's name.
diff --git a/src/libsyntax_pos/symbol.rs b/src/libsyntax_pos/symbol.rs
index 7d43c3c8d076e93bc347bff192bdfbfed4937579..3059b059691067c51966b1646a1bcc35ec6e7892 100644
--- a/src/libsyntax_pos/symbol.rs
+++ b/src/libsyntax_pos/symbol.rs
@@ -177,6 +177,7 @@
         cfg_attr,
         cfg_attr_multi,
         cfg_doctest,
+        cfg_sanitize,
         cfg_target_feature,
         cfg_target_has_atomic,
         cfg_target_thread_local,
@@ -634,6 +635,7 @@
         rust_eh_unwind_resume,
         rust_oom,
         rvalue_static_promotion,
+        sanitize,
         sanitizer_runtime,
         _Self,
         self_in_typedefs,
diff --git a/src/test/ui/feature-gates/feature-gate-cfg_sanitize.rs b/src/test/ui/feature-gates/feature-gate-cfg_sanitize.rs
new file mode 100644
index 0000000000000000000000000000000000000000..c3e7cc9ed8a9bcbe1252abf0cf281aaddcc2ac79
--- /dev/null
+++ b/src/test/ui/feature-gates/feature-gate-cfg_sanitize.rs
@@ -0,0 +1,3 @@
+#[cfg(not(sanitize = "thread"))]
+//~^ `cfg(sanitize)` is experimental
+fn main() {}
diff --git a/src/test/ui/feature-gates/feature-gate-cfg_sanitize.stderr b/src/test/ui/feature-gates/feature-gate-cfg_sanitize.stderr
new file mode 100644
index 0000000000000000000000000000000000000000..f67a0d83bdd3a1fab70eddaa13cf86d91cf6edf2
--- /dev/null
+++ b/src/test/ui/feature-gates/feature-gate-cfg_sanitize.stderr
@@ -0,0 +1,12 @@
+error[E0658]: `cfg(sanitize)` is experimental and subject to change
+  --> $DIR/feature-gate-cfg_sanitize.rs:1:11
+   |
+LL | #[cfg(not(sanitize = "thread"))]
+   |           ^^^^^^^^^^^^^^^^^^^
+   |
+   = note: for more information, see https://github.com/rust-lang/rust/issues/39699
+   = help: add `#![feature(cfg_sanitize)]` to the crate attributes to enable
+
+error: aborting due to previous error
+
+For more information about this error, try `rustc --explain E0658`.
diff --git a/src/test/ui/sanitize-cfg.rs b/src/test/ui/sanitize-cfg.rs
new file mode 100644
index 0000000000000000000000000000000000000000..9c198543a86649572cd42aa4fc6105d4231b985b
--- /dev/null
+++ b/src/test/ui/sanitize-cfg.rs
@@ -0,0 +1,26 @@
+// Verifies that when compiling with -Zsanitizer=option,
+// the `#[cfg(sanitize = "option")]` attribute is configured.
+
+// needs-sanitizer-support
+// only-linux
+// only-x86_64
+// check-pass
+// revisions: address leak memory thread
+//[address]compile-flags: -Zsanitizer=address --cfg address
+//[leak]compile-flags:    -Zsanitizer=leak    --cfg leak
+//[memory]compile-flags:  -Zsanitizer=memory  --cfg memory
+//[thread]compile-flags:  -Zsanitizer=thread  --cfg thread
+
+#![feature(cfg_sanitize)]
+
+#[cfg(all(sanitize = "address", address))]
+fn main() {}
+
+#[cfg(all(sanitize = "leak", leak))]
+fn main() {}
+
+#[cfg(all(sanitize = "memory", memory))]
+fn main() {}
+
+#[cfg(all(sanitize = "thread", thread))]
+fn main() {}