diff --git a/python/paddle/fluid/tests/unittests/CMakeLists.txt b/python/paddle/fluid/tests/unittests/CMakeLists.txt
index 9614aa72f98274b5e03751aeb90670c511a2ae79..ae706fadcee8a2057622d64c0b9b0943e779ac03 100644
--- a/python/paddle/fluid/tests/unittests/CMakeLists.txt
+++ b/python/paddle/fluid/tests/unittests/CMakeLists.txt
@@ -53,7 +53,7 @@ endif()
 list(REMOVE_ITEM TEST_OPS test_seq_concat_op) # FIXME(helin): https://github.com/PaddlePaddle/Paddle/issues/8290
 list(REMOVE_ITEM TEST_OPS test_lstm_unit_op) # # FIXME(qijun) https://github.com/PaddlePaddle/Paddle/issues/5185
 list(REMOVE_ITEM TEST_OPS test_cond_op) # FIXME(qijun): https://github.com/PaddlePaddle/Paddle/issues/5101#issuecomment-339814957
-
+list(REMOVE_ITEM TEST_OPS test_kldiv_loss_op) # FIXME(dengkaipeng): https://github.com/PaddlePaddle/Paddle/issues/21750
 
 list(REMOVE_ITEM TEST_OPS op_test) # op_test is a helper python file, not a test
 list(REMOVE_ITEM TEST_OPS decorator_helper) # decorator_helper is a helper python file, not a test