diff --git a/paddle/fluid/framework/custom_operator.h b/paddle/fluid/framework/custom_operator.h
index 117841f80cf47ed95251fee1d01f7fd87caa600b..259901c09f3e00729876d7bea062237ad5bad94a 100644
--- a/paddle/fluid/framework/custom_operator.h
+++ b/paddle/fluid/framework/custom_operator.h
@@ -28,5 +28,8 @@ void LoadOpMetaInfoAndRegisterOp(const std::string& dso_name);
 void RegisterOperatorWithMetaInfoMap(
     const paddle::OpMetaInfoMap& op_meta_info_map);
 
+// Interface for selective register custom op.
+void RegisterOperatorWithMetaInfo(const std::vector<OpMetaInfo>& op_meta_infos);
+
 }  // namespace framework
 }  // namespace paddle
diff --git a/paddle/fluid/inference/api/CMakeLists.txt b/paddle/fluid/inference/api/CMakeLists.txt
index 03f86cc7ba6de608f2f755ad5ff0f76578575575..82c95ba2c95712d2ebe3aa80286689028febf3fe 100755
--- a/paddle/fluid/inference/api/CMakeLists.txt
+++ b/paddle/fluid/inference/api/CMakeLists.txt
@@ -32,10 +32,10 @@ cc_library(paddle_pass_builder SRCS paddle_pass_builder.cc)
 
 if(WITH_CRYPTO)
     cc_library(paddle_inference_api SRCS api.cc api_impl.cc helper.cc DEPS lod_tensor scope reset_tensor_array 
-              analysis_config zero_copy_tensor trainer_desc_proto paddle_crypto)
+              analysis_config zero_copy_tensor trainer_desc_proto paddle_crypto custom_operator)
 else()
     cc_library(paddle_inference_api SRCS api.cc api_impl.cc helper.cc DEPS lod_tensor scope reset_tensor_array 
-              analysis_config zero_copy_tensor trainer_desc_proto)
+              analysis_config zero_copy_tensor trainer_desc_proto custom_operator)
 endif()
 
 if(WIN32)
diff --git a/paddle/fluid/inference/api/analysis_predictor.cc b/paddle/fluid/inference/api/analysis_predictor.cc
index 95b08318368438943b538774cbeb83e2d92a5103..6a6be14fd5977dcb7a7909b17a7684780391042c 100644
--- a/paddle/fluid/inference/api/analysis_predictor.cc
+++ b/paddle/fluid/inference/api/analysis_predictor.cc
@@ -628,7 +628,7 @@ std::unique_ptr<PaddlePredictor> CreatePaddlePredictor<
   // This function can only be executed once per process.
   static std::once_flag custom_operators_registered;
   std::call_once(custom_operators_registered,
-                 []() { paddle::RegisterAllCustomOperator(); });
+                 []() { inference::RegisterAllCustomOperator(); });
 
   if (config.use_gpu()) {
     static std::once_flag gflags_initialized;
diff --git a/paddle/fluid/inference/api/helper.cc b/paddle/fluid/inference/api/helper.cc
index 9cc491e10d691a206dd903b78c0ea570741da44c..d78560239de50eb224641583d62b55bac75be465 100644
--- a/paddle/fluid/inference/api/helper.cc
+++ b/paddle/fluid/inference/api/helper.cc
@@ -13,6 +13,9 @@
 // limitations under the License.
 
 #include "paddle/fluid/inference/api/helper.h"
+#include "paddle/fluid/extension/include/ext_op_meta_info.h"
+#include "paddle/fluid/framework/custom_operator.h"
+#include "paddle/fluid/framework/operator.h"
 
 namespace paddle {
 namespace inference {
@@ -40,5 +43,20 @@ std::string to_string<std::vector<std::vector<float>>>(
   return ss.str();
 }
 
+void RegisterAllCustomOperator() {
+  auto &op_meta_info_map = OpMetaInfoMap::Instance();
+  const auto &meta_info_map = op_meta_info_map.GetMap();
+  for (auto &pair : meta_info_map) {
+    const auto &all_op_kernels{framework::OperatorWithKernel::AllOpKernels()};
+    if (all_op_kernels.find(pair.first) == all_op_kernels.end()) {
+      framework::RegisterOperatorWithMetaInfo(pair.second);
+    } else {
+      LOG(INFO) << "The operator `" << pair.first
+                << "` has been registered. "
+                   "Therefore, we will not repeat the registration here.";
+    }
+  }
+}
+
 }  // namespace inference
 }  // namespace paddle
diff --git a/paddle/fluid/inference/api/helper.h b/paddle/fluid/inference/api/helper.h
index 14b968f5834da8618f6af16aa8c25e1d1baaae5e..c6d25137594b76a1ff67d9fb25b2480372c3eefa 100644
--- a/paddle/fluid/inference/api/helper.h
+++ b/paddle/fluid/inference/api/helper.h
@@ -398,5 +398,7 @@ static bool IsFileExists(const std::string &path) {
   return exists;
 }
 
+void RegisterAllCustomOperator();
+
 }  // namespace inference
 }  // namespace paddle
diff --git a/python/paddle/fluid/tests/custom_op/test_custom_relu_op_setup.py b/python/paddle/fluid/tests/custom_op/test_custom_relu_op_setup.py
index 7f5c76d0aeeae3a20b3310144dfc8f45c6461f84..642e93ebcb85e0eab3aa373243d7b44b42aab443 100644
--- a/python/paddle/fluid/tests/custom_op/test_custom_relu_op_setup.py
+++ b/python/paddle/fluid/tests/custom_op/test_custom_relu_op_setup.py
@@ -255,6 +255,35 @@ class TestNewCustomOpSetUpInstall(unittest.TestCase):
                     format(predict, predict_infer))
         paddle.disable_static()
 
+    def test_static_save_and_run_inference_predictor(self):
+        paddle.enable_static()
+        np_data = np.random.random((1, 1, 28, 28)).astype("float32")
+        np_label = np.random.random((1, 1)).astype("int64")
+        path_prefix = "custom_op_inference/custom_relu"
+        from paddle.inference import Config
+        from paddle.inference import create_predictor
+        for device in self.devices:
+            predict = custom_relu_static_inference(
+                self.custom_ops[0], device, np_data, np_label, path_prefix)
+            # load inference model
+            config = Config(path_prefix + ".pdmodel",
+                            path_prefix + ".pdiparams")
+            predictor = create_predictor(config)
+            input_tensor = predictor.get_input_handle(predictor.get_input_names(
+            )[0])
+            input_tensor.reshape(np_data.shape)
+            input_tensor.copy_from_cpu(np_data.copy())
+            predictor.run()
+            output_tensor = predictor.get_output_handle(
+                predictor.get_output_names()[0])
+            predict_infer = output_tensor.copy_to_cpu()
+            self.assertTrue(
+                np.isclose(
+                    predict, predict_infer, rtol=5e-5).any(),
+                "custom op predict: {},\n custom op infer predict: {}".format(
+                    predict, predict_infer))
+        paddle.disable_static()
+
 
 if __name__ == '__main__':
     unittest.main()